Cinnamic Acid - Effective Treatment of Lung Adenocarcinoma

Most lung adenocarcinomas originate from smaller bronchial mucosal mucinous epithelial cells and grow in the mucous glands of the small bronchial bronchi of the lungs. Therefore, adenocarcinoma is most common in peripheral lung cancer. Adenocarcinoma accounts for about 25% of primary lung cancer. Adenocarcinomas tend to grow outside the tube, but they also spread through the wall and often form lumps of 2–4 cm in diameter at the edges of the lungs. Adenocarcinoma is rich in blood vessels, so local infiltration and hematogenous metastasis are earlier than squamous cell carcinoma. Easy to transfer to the liver, brain and bone, more easily involving the pleura and cause pleural effusion. Lung adenocarcinoma does not have any special symptoms in the early stages. It is only common symptoms of general respiratory diseases such as cough, sputum, low fever, chest pain, and bloating, which are easily overlooked by patients and doctors.

To date, no effective method for completely curing lung adenocarcinoma has been found in the world medical field. In China, how to treat lung adenocarcinoma effectively is also a hot topic. Currently, experts from Henan Medical University have confirmed that cinnamic acid is a potentially useful inducing agent by studying the effects of cinnamic acid on tumor cells. Therefore, attempts were made to use cinnamic acid (CINN) to induce differentiation of lung adenocarcinoma cells (A549 cells). Experts compared the experimental group of lung adenocarcinoma cells containing the CINN with the blank lung adenocarcinoma experimental group and found that the experimental group containing cinnamic acid was significantly inhibited than the control group A549 cell proliferation, and this inhibitory effect with the concentration of CINN Increase and increase. In addition, no significant cell death was observed in each concentration of CINN induced treatment. Therefore, the inhibitory effect of CINN on the proliferation of A549 cells was non-cytotoxic. After removing CINN, the A549 virus was still in a growth-inhibitory state, which persisted throughout the experimental observation period and did not rebound.

Induction of cancer cell differentiation is an important means to reverse cancer cells. In recent years, many effective differentiation-inducing substances have been discovered, and it is of particular importance to find natural substances as tumor cell differentiation inducers against cancer. Numerous data indicate that cell proliferation and differentiation are negatively correlated. Cell division and slowing down of proliferation rate are often the result of cell differentiation. Continuous induction of lung adenocarcinoma cells with cinnamic acid significantly slowed cell growth, prolonged doubling time, reduced mitotic cells, and did not see dramatic cell death and apparent morphological destruction. In addition, the number of differentiated cells of lung adenocarcinoma cells increased significantly with cinnamic acid. This shows that cinnamic acid has a strong induction of differentiation on lung adenocarcinoma cells, and it is non-cytotoxic.

At present, some manufacturers have begun to use cinnamic acid to start developing drugs for the treatment of lung adenocarcinoma, I believe in the near future, effective treatment of lung adenocarcinoma will no longer be a dream!